Role of serotonergic 1A receptor dysfunction in depression associated with Parkinson's disease.
Identifieur interne : 000091 ( France/Analysis ); précédent : 000090; suivant : 000092Role of serotonergic 1A receptor dysfunction in depression associated with Parkinson's disease.
Auteurs : Benedicte Ballanger [France] ; Helene Klinger ; Julien Eche ; Jérôme Lerond ; Anne-Evelyne Vallet ; Didier Le Bars ; Leon Tremblay ; Véronique Sgambato-Faure ; Emmanuel Broussolle ; Stéphane ThoboisSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2012.
English descriptors
- KwdEn :
- Adult, Aged, Aminopyridines (pharmacokinetics), Brain (drug effects), Brain (radionuclide imaging), Depression (etiology), Depression (radionuclide imaging), Female, Fluorine Radioisotopes (diagnostic use), Humans, Magnetic Resonance Imaging, Male, Middle Aged, Parkinson Disease (complications), Parkinson Disease (radionuclide imaging), Piperazines (pharmacokinetics), Positron-Emission Tomography, Receptor, Serotonin, 5-HT1A (metabolism), Serotonin Antagonists (pharmacokinetics).
- MESH :
- chemical , diagnostic use : Fluorine Radioisotopes.
- chemical , metabolism : Receptor, Serotonin, 5-HT1A.
- chemical , pharmacokinetics : Aminopyridines, Piperazines, Serotonin Antagonists.
- complications : Parkinson Disease.
- drug effects : Brain.
- etiology : Depression.
- radionuclide imaging : Brain, Depression, Parkinson Disease.
- Adult, Aged, Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Positron-Emission Tomography.
Abstract
Depression is frequent in Parkinson's disease, but its pathophysiology remains unclear. Two recent studies have investigated the role of serotonergic system at the presynaptic level. The objective of the present study was to use positron emission tomography and [(18)F]MPPF to investigate the role of postsynaptic serotonergic system dysfunction in the pathophysiology of depression in Parkinson's disease. Four parkinsonian patients with depression and 8 parkinsonian patients without depression were enrolled. Each patient underwent a scan using [(18)F]MPPF, a selective serotonin 1A receptor antagonist. Voxel-by-voxel statistical comparison of [(18)F]MPPF uptake of the 2 groups of parkinsonian patients and with 7 matched normal subjects was made using statistical parametric mapping (P uncorrected < .001). Compared with nondepressed parkinsonian patients, depressed patients exhibited reduced tracer uptake in the left hippocampus, the right insula, the left superior temporal cortex, and the orbitofrontal cortex. Compared with controls, nondepressed parkinsonian patients presented reduced [(18)F]MPPF uptake bilaterally in the inferior frontal cortex as well as in the right ventral striatum and insula. Compared with controls, [(18)F]MPPF uptake was decreased in depressed parkinsonian patients in the left dorsal anterior cingulate and orbitofrontal cortices, in the right hippocampic region, and in the temporal cortex. The present imaging study suggests that abnormalities in serotonin 1A receptor neurotransmission in the limbic system may be involved in the neural mechanisms underlying depression in patients with Parkinson's disease.
DOI: 10.1002/mds.23895
PubMed: 21994070
Affiliations:
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pubmed:21994070Le document en format XML
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<front><div type="abstract" xml:lang="en">Depression is frequent in Parkinson's disease, but its pathophysiology remains unclear. Two recent studies have investigated the role of serotonergic system at the presynaptic level. The objective of the present study was to use positron emission tomography and [(18)F]MPPF to investigate the role of postsynaptic serotonergic system dysfunction in the pathophysiology of depression in Parkinson's disease. Four parkinsonian patients with depression and 8 parkinsonian patients without depression were enrolled. Each patient underwent a scan using [(18)F]MPPF, a selective serotonin 1A receptor antagonist. Voxel-by-voxel statistical comparison of [(18)F]MPPF uptake of the 2 groups of parkinsonian patients and with 7 matched normal subjects was made using statistical parametric mapping (P uncorrected < .001). Compared with nondepressed parkinsonian patients, depressed patients exhibited reduced tracer uptake in the left hippocampus, the right insula, the left superior temporal cortex, and the orbitofrontal cortex. Compared with controls, nondepressed parkinsonian patients presented reduced [(18)F]MPPF uptake bilaterally in the inferior frontal cortex as well as in the right ventral striatum and insula. Compared with controls, [(18)F]MPPF uptake was decreased in depressed parkinsonian patients in the left dorsal anterior cingulate and orbitofrontal cortices, in the right hippocampic region, and in the temporal cortex. The present imaging study suggests that abnormalities in serotonin 1A receptor neurotransmission in the limbic system may be involved in the neural mechanisms underlying depression in patients with Parkinson's disease.</div>
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